Article

Mediators of asthma outcomes.

Johns Hopkins University, Baltimore, MD, USA.
The Journal of allergy and clinical immunology (impact factor: 9.17). 03/2012; 129(3 Suppl):S136-41. DOI:10.1016/j.jaci.2011.12.987 pp.S136-41
Source: PubMed

ABSTRACT Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators.
National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators.
We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature.
The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants.
Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions.

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Keywords

asthma clinical research
 
asthma clinical research outcomes measures
 
asthma outcome mediators
 
asthma outcomes
 
asthma self-management skills
 
brief review
 
brief summary
 
clinical research participants
 
federal agencies
 
Health institutes
 
key mediators
 
National Institutes
 
Patient adherence
 
potential impact
 
potential mediators
 
self-management skills
 
specific outcome topic
 
standardized measures
 
study participants
 
treatment interventions