P300 latency reflects the degree of cognitive decline in dementing illness
ABSTRACT An auditory discrimination paradigm was employed to elicit the P3 component of the event-related brain potential (ERP) from 39 demented patients (mean age = 71 years). Component latency was longer in patients who were diagnosed as having primary degenerative dementia and other cognitive impairment disorders compared to age-matched controls. Neurologist ratings of cognitive impairment were significantly correlated with P3 latency values, although no differences in mean latency were obtained between the various categories of dementia. ERP measurement techniques and the interpretation of P3 latency as an index of dementing illness are discussed.
SourceAvailable from: Leontios Hadjileontiadis[Show abstract] [Hide abstract]
ABSTRACT: MMN and P300 present smaller amplitude and longer latencies with age.•Brain source localization of P300 and maximum current field intensity shift significantly with age.•Brain source localization of ERP components is gender related, with more pronounced differences in younger age.
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ABSTRACT: To objectively assess the clinical effects of nicergo-line on demented patients, we recorded the P300 component of event-related potentials (ERPs) during an oddball paradigm before and after the administration of nicergoline in 17 patients with multi-infarct dementia. The patients received nicergoline (15 mg/day) for four weeks. ERPs were derived from the Fz, Cz, and Pz regions. Infrequent target tones elicited P300 components. After the administration of nicergoline, P300 amplitude increased and P300 latency decreased significantly, which indicated improved cognitive function in the patients. The results in this study suggest that the P300 component is a sensitive index for the effects of cerebral-metabolic enhancers.
Conference Paper: Aging and Attentional Set Shifting on WCST: An event related EEG study[Show abstract] [Hide abstract]
ABSTRACT: As the brain ages, it suffers several neurochemical, structural and functional changes. These deficits are primarily reflected on daily memory tasks. In the present work, we use the Wisconsin Card Sorting Task (WCST) task to assess P300 component of the event-related potential (ERP) as a marker for aging. Considering age-related effects, WCST was applied to young, middle-aged and elder participants. Early-late trial analysis tested the attentional set shifting and working memory updating hypothesis for the mechanisms behind WCST. The results suggest that, as people age, P3b peak latency highly correlates with age on both early and late trials, increasing as people gets older. P3b peak amplitude significantly distinguished between early and late trials regardless the subjects' age, while there were no differences on P300 peak latency.7th Annual International IEEE EMBS Conference on Neural Engineering; 04/2015