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Why Helicobacter pylori has Lewis antigens

Institute for Biological Sciences, NRC, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
Trends in Microbiology (Impact Factor: 9.81). 01/2001; 8(12):565-570. DOI: 10.1016/S0966-842X(00)01875-8

ABSTRACT In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

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    • "However, there are contradictory observations about these hypotheses. Currently, the best evidence for the role of H. pylori Lewis glycans is that they may play a role in the adhesion or colonization of the bacterium to the host gastric mucosa (reviewed in Appelmelk et al., 2000; Gerhard et al., 2002; Moran and Prendergast, 2001). Especially, H. pylori Le x has been suggested to mediate adhesion to gastric epithelial cells and to be essential for colonization (Appelmelk and Vandenbroucke-Grauls, 2000; Edwards et al., 2000; Martin et al., 2000; Osaki et al., 1998). "
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    • "To this end, we are assembling gastric histological material taken at the time of H. pylori culture from the majority of the patients. The selectin binding we have observed is distinct from the previously reported, carbohydrate-mediated interactions of H. pylori [14]. Among these are interactions with gastric epithelial cells mediated by the bacterial Fig. 2. Inhibition of E-and L-selectin binding to suspensions of H. pylori isolates by selectin ligands or EDTA. "
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    ABSTRACT: Diss. -- Helsingin yliopisto.
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