Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives

Departamento de Química Orgánica, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay; Departamento de Fisicoquímica Biológica, Facultad de Ciencias, Universidad de la República, 11200 Montevideo, Uruguay; Departamento de Química Cuántica, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay
Il Farmaco 03/1998; DOI: 10.1016/S0014-827X(97)00011-6

ABSTRACT Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti-trypanosomal agents. The compounds were prepared in good to excellent yields in 2–3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox.

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