Article

Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice

Ahmadu Bello University, Заря, Kaduna, Nigeria
Journal of Ethnopharmacology (Impact Factor: 2.94). 02/2005; 97(1):53-57. DOI: 10.1016/j.jep.2004.10.003

ABSTRACT The present study evaluated the neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rodents. Effects on the spontaneous motor activity (SMA), exploratory behaviour, pentobarbital sleeping time, apomorphine-induced stereotypic behaviour and motor coordination (rota-rod performance) were investigated. The extract (50–200 mg/kg p.o.) significantly (P < 0.05) decreased the SMA and exploratory behaviour in mice and prolonged pentobarbital sleeping time in rats dose-dependently. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy dose-dependently in mice, but had no effect on motor coordination as determined by the performance on rota-rod. These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia.

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    • "and staying on the same spot (5). The stereotypic behavior was rated after each minute and mean of 15 min period was calculated and recorded (Amos et al. 2005; Erbas and Taskiran 2014). Assessment of stereotyped behavior was performed by two observers blind to the study groups. "
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    • "Signs of stereotypy, which contain generally sniffing and gnawing, were inspected and scored as follows: absence of stereotypy (0), rarely sniffing (1), rarely sniffing with rarely gnawing (2), frequent gnawing (3), intense continuous gnawing (4), and intense gnawing and staying on the same spot (5). The stereotypic behavior was rated after every minute, and mean of 15 min period was calculated and recorded [30] [31] [32]. "
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    International Journal of Clinical and Experimental Medicine 10/2014; 7(10):3354-3361. · 1.42 Impact Factor
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    • "Signs of stereotypy , which include mainly sniffing and gnawing, were observed and scored as follows: absence of stereotypy (0), occasional sniffing (1), occasional sniffing with occasional gnawing (2), frequent gnawing (3), intense continuous gnawing (4), and intense gnawing and staying on the same spot (5). The stereotypic behavior was rated after each minute and mean of 15-min period was calculated and recorded [21] "
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