Article

The fight of viruses against apoptosis

Institut für Klinische und Molekulare Virologie, Schlossgarten 4, D-91054 Erlangen, Germany
Current Opinion in Genetics & Development (Impact Factor: 8.57). 02/1998; DOI: 10.1016/S0959-437X(98)80066-X

ABSTRACT The induction of apoptosis of virus-infected cells is an important host defense mechanism against invading pathogens. Some viruses express anti-apoptotic proteins that efficiently block apoptosis induced by death receptors or in response to stress signaled through mitochondria. Viral interference with host cell apoptosis leads to enhanced viral replication and may promote cancer.

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