With a surface area of nearly 900,000 km2, the Guiana Shield represents the northern segment of the Amazonian Craton in South America, lying for the most part between the Amazon and Orinoco river basins. Most of the Guiana Shield formed during protracted periods of intense magmatism, metamorphism and deformation, culminating with the Trans-Amazonian tectono-thermal event, bracketed between 2.1 and 1.9 Ga.The Guiana Shield is among the least known Precambrian terranes because it is relatively inaccessible, lacks bedrock exposure due to intense weathering and is poorly documented in the international geological literature. This situation has significantly improved during the last 20 years, when shallow in situ gold occurrences attracted exploration and mining companies to initiate geological programs aimed at better understanding the geology and the mineral deposits of the Shield.The only Archean terrane (ca. 3400 Ma) known to date in the Guiana Shield is the Imataca Complex in Venezuela. The Paleoproterozoic low-grade volcano–sedimentary greenstone sequences and associated granitoid intrusions have yielded ages between 2.25 and 2.08 Ga. Recent U–Pb age determinations of the granitoid–greenstone belts suggest protracted magmatic cycles from pre- to post-peak regional metamorphism. The younger terranes comprise anorogenic sedimentary sequences of the Roraima Formation, as well as felsic volcanic rocks and associated intrusions of the Uatuma Formation, mafic dikes of the Avanavero Suite and Rapakivi-type and alkali intrusions.Several large-scale ductile shear zones have been documented in the Guiana Shield. In northcentral Venezuela, the most outstanding structure documented to date, the NE–SW trending Guri Fault, juxtaposes the Archean Imataca complex against Paleoproterozoic terranes. The Central Guiana Shear Zone (CGSZ) extends from French Guiana westerly towards central Suriname and further west towards northcentral Guyana, where it matches with the Makapa–Kuribrong shear zone (MKSZ). In French Guiana, the North Guiana Trough (NGT) is interpreted as a sinistral strike-slip formed during the Trans-Amazonian orogeny.Most gold deposits and occurrences discovered to date in the Guiana Shield are sited in close proximity to major structures. In addition, they are linked with low- to medium metamorphic-grade granitoid–greenstone belts, similar to other better-explored Precambrian terranes. At a local scale, the gold deposits are hosted within, or in close proximity to, quartz veins that are syn- to late-tectonic, and to a lesser extent, in stockworks, breccias, and lenses. They are commonly located in units that behaved in a more brittle manner than the country rocks. Available information suggests that gold deposits are mainly epigenetic, although some are associated with specific lithostratigraphic units. Pyrite, pyrrhotite, chalcopyrite, galena, sphalerite, scheelite, molybdenite and tellurides are the main metallic minerals associated with gold. Non-metallic minerals are mainly quartz and carbonates (ankerite, calcite, siderite), associated with minor chlorite, epidote, albite, muscovite and fuchsite. Silica, carbonate, propylitic and potassic alteration is common.High erosion rates expected after the creation of an orogenic belt did not occur in the northern Guiana Shield. Shallow-level deposits preserved in many settings suggest that the granitoid–greenstone belts represent first-order exploration targets for large tonnage/low-grade gold deposits.