Depressive symptoms predict exaggerated inflammatory responses to an

Department of Psychology, The Ohio State University, Columbus, Ohio, USA
Brain Behavior and Immunity (Impact Factor: 6.13). 07/2013; 24(1):49-53. DOI: 10.1016/j.bbi.2009.05.055

ABSTRACT ObjectiveStress and depressive symptoms predict exaggerated inflammatory responses to a biological challenge in nonpregnant humans and animals. The extent to which these findings generalize to pregnancy is unknown because the immune system exhibits substantial changes to support pregnancy. Notably, inflammatory responses to infectious agents play a causal role in the development of gestational hypertension as well as risk for preterm birth. Thus, depressive symptoms may increase susceptibility to these outcomes via sensitization of inflammatory processes. The current study was designed to test the hypothesis that depressive symptoms would predict an exaggerated proinflammatory response to an in vivo antigen challenge, influenza virus vaccination, among pregnant women.MethodTwenty-two pregnant women completed two study visits: baseline and 1 week after receiving influenza virus vaccination. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale (CES-D) at baseline. Serum levels of macrophage migration inhibitory factor (MIF) were determined using a high sensitivity immunoassay at both study visits.OutcomesAnalyses demonstrated that, as compared to those in the lowest tertile of CES-D scores, those in the highest tertile exhibited significantly higher levels of MIF 1 week after influenza virus vaccination (p = .035).ConclusionsDepressive symptoms predicted exaggerated MIF production following influenza virus vaccination during pregnancy. These data support the hypothesis that depressive symptoms are associated with sensitization of the inflammatory response during pregnancy. Thus, women with greater depressive symptoms may be more vulnerable to negative sequelae of infectious illness during pregnancy.

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Available from: Lisa M Christian, Aug 26, 2015
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    • "of response have been reported in patients with stable vs. unstable forms of coronary heart disease [17]. Exaggerated inflammatory responses to influenza vaccination have also been associated with greater depressive symptoms in older adults [13], and among pregnant women [18]. These studies underscore the potential value of influenza vaccination as a mild, controlled stimulus for investigating individual differences in inflammatory responses in vivo. "
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    Vaccine 03/2015; 33(17). DOI:10.1016/j.vaccine.2015.03.019 · 3.49 Impact Factor
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    • "This study examined serum proinflammatory proteins, but did not examine inflammatory responses to a stimulus. Such data would be highly informative, as prior studies show that conditions with an inflammatory component including depression and coronary artery disease as well as obesity are associated with dysregulation of inflammatory responses [61] [62] [63] [64]. Moreover, despite elevations in serum proinflammatory markers during pregnancy versus non-pregnancy, available evidence from both human and animal studies indicates that inflammatory responses are attenuated [65] [66] [67] [68] [69]. "
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    • "In terms of immune parameters, inflammatory markers have been a primary focus. Factors including a, and IL-1RA in pregnant women (Coussons-Read et al., 2005; Ruiz et al., 2007; Paul et al., 2008; Christian et al., 2009; Blackmore et al., 2011; Cassidy-Bushrow et al., 2012) as well as exaggerated inflammatory responses to in vivo and in vitro immune challenges (Coussons-Read et al., 2007; Christian et al., 2010). Linking such effects to birth outcomes, in a study of 173 women followed across pregnancy, an association between prenatal stress and gestational age at birth was mediated by levels of circulating inflammatory markers (Coussons-Read et al., 2012). "
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