Detecting spatiotemporal nonlinear dynamics in resting state of human brain based on fMRI datasets

Physics Department, Zhejiang University, Hangzhou, 310027 Zhejiang, China; Laboratory for Higher Brain Function, Institute of Psychology, The Chinese Academy of Sciences, Beijing 100101, China
Applied Mathematics and Computation (Impact Factor: 1.35). 01/2008; DOI: 10.1016/j.amc.2008.05.102
Source: DBLP

ABSTRACT In this work, a nonlinear dynamics method, coupled map lattices, was applied to functional magnetic resonance imaging (fMRI) datasets to examine the spatiotemporal properties of resting state blood oxygen level-dependent (BOLD) fluctuations. Spatiotemporal Lyapunov Exponent (SPLE) was calculated to study the deterministic nonlinearity in resting state human brain of nine subjects based on fMRI datasets. The results show that there is nonlinearity and determinism in resting state human brain. Furthermore, the results demonstrate that there is a spatiotemporal chaos phenomenon in resting state brain, and suggest that fluctuations of fMRI data in resting state brain cannot be fully attributed to nuclear magnetic resonance noise. At the same time, the spatiotemporal chaos phenomenon suggests that the correlation between voxels varies with time and there is a dynamic functional connection or network in resting state human brain.

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