Article

Chapter 3.2 Microdialysis coupled with liquid chromatography/mass spectrometry

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Handbook of Behavioral Neuroscience DOI:10.1016/S1569-7339(06)16014-2 pp.251-266

ABSTRACT This chapter describes basic principles and protocols in the field of microdialysis combined with liquid chromatography/mass spectrometry (LC/MS). We describe currently used separation methods coupled with MS and its application to in vivo microdialysis in the central nervous system. Newly developed strategies and analytical methods are discussed for the study of drug pharmacokinetics, neuropeptide metabolism, and treatment-induced or disease-specific effects on the “neuropeptidome”.

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Keywords

basic principles
 
central nervous system
 
drug pharmacokinetics
 
LC/MS
 
liquid chromatography/mass spectrometry
 
microdialysis
 
neuropeptide metabolism
 
treatment-induced
 
vivo microdialysis