Connections between the cochlear nuclei in guinea pig

Department of Otolaryngology, Medical College of Ohio, Toledo, Ohio, USA; Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA
Hearing Research (Impact Factor: 2.54). 10/1992; DOI: 10.1016/0378-5955(92)90199-W
Source: PubMed

ABSTRACT This study provides a detailed analysis of the appearances and distributions of neurons projecting from one cochlear nucleus to the other. Injections of wheatgerm agglutinin conjugated to horseradish peroxidase were made into ventral or dorsal cochlear nucleus of the guinea pig. Retrogradely labeled cells in the opposite cochlear nucleus were examined and quantified. Three major categories of labeled cells were discerned on the basis of their soma shape: elongate, round-to-oval, and polygonal. All injections resulted in widespread labeling of cells in all of these categories, but especially round-to-oval cells, in the opposite ventral cochlear nucleus and sparse labeling in the dorsal cochlear nucleus. The results suggest that there is a significant cochlear nucleus commissural projection involving heterogeneous cell types which could have diverse functions in binaural auditory signal processing.

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