Prisby, R. D., Lafage-Proust, M. H., Malaval, L., Belli, A. & Vico, L. Effects of whole body vibration on the skeleton and other organ systems in man and animal models: what we know and what we need to know. Ageing Res. Rev. 7, 319-329

Université Jean-Monnet, Saint-Etienne F42023, France
Ageing research reviews (Impact Factor: 4.94). 12/2008; 7(4):319-329. DOI: 10.1016/j.arr.2008.07.004
Source: PubMed


Previous investigations reported enhanced osseous parameters subsequent to administration of whole body vibration (WBV). While the efficacy of WBV continues to be explored, scientific inquiries should consider several key factors. Bone remodeling patterns differ according to age and hormonal status. Therefore, WBV protocols should be designed specifically for the subject population investigated. Further, administration of WBV to individuals at greatest risk for osteoporosis may elicit secondary physiological benefits (e.g., improved balance and mobility). Secondly, there is a paucity of data in the literature regarding the physiological modulation of WBV on other organ systems and tissues. Vibration-induced modulation of systemic hormones may provide a mechanism by which skeletal tissue is enhanced. Lastly, the most appropriate frequencies, durations, and amplitudes of vibration necessary for a beneficial response are unknown, and the type of vibratory signal (e.g., sinusoidal) is often not reported. This review summarizes the physiological responses of several organ systems in an attempt to link the global influence of WBV. Further, we report findings focused on subject populations that may benefit most from such a therapy (i.e., the elderly, postmenopausal women, etc.) in hopes of eliciting multidisciplinary scientific inquiries into this potentially therapeutic aid which presumably has global ramifications.

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    • "An effect in the muscle with a local consequence and/or with interference in the central nervous system can be suggested as direct effect. Moreover, the action in the central nervous system can induce fluctuations in the plasma concentration of hormonal and non hormonal biomarkers (Prisby et al., 2008; Rittweger, 2010; Cochrane, 2011). Importance of the neuroendocrine response to the vibrations seems to be clear due to the hormone fluctuations demonstrated for several authors (Di Loreto et al., 2004; Goto and Takamatsu, 2005; Cardinale et al., 2010; Santos-Filho et al., 2011; Di Giminiani et al., 2014) in subjects submitted to this physical agent. "
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    ABSTRACT: Vibration is a mechanical stimulus that is characterized by an oscillatory motion. When there is a direct contact of a person, in general standing on the base of this type of platform, the vibration that is produced in these machines is transmitted to the body of the subject producing whole body vibration (WBV) exercises. Biological effects can be associated with the WBV exercises with desirable and undesirable consequences. These effects of the WBV exercises seem to be related to a direct effect in a tissue/organ/system and/or or to indirect effects due to alteration of the plasma concentration of some hormonal and non hormonal biomarkers. The aim of this investigation is to present a revision about hormonal and non hormonal biomarkers in human beings submitted to WBV exercises that have suffered alteration in the plasma concentrations. Searches were performed in the PubMed and Scopus databases with the key words " whole body vibration ". Papers were selected following defined criteria. Considering the WBV exercise, hormonal fluctuations of testosterone, growth, insulin-like growth factor1, epinephrine, norepinephrine, cortisol, irisin, parathyroid hormone and sclerotin are observed. Non hormonal biomarkers have suffered alterations in response to WBV, as glucose, free fatty acids, adiponectin, transforming growth factor-beta1, nitric oxide, osteopontin, interleukin-1beta, bone-specific alkaline phosphatase, cartilage oligometric matrix protein and tumor necrosis factor-alpha in plasma concentration. In conclusion, putting together the findings related to the alterations of the concentration of hormonal and non hormonal biomarkers due to the WBV exercises, it is possible that the fluctuations in the plasma concentrations of these biomarkers might help us understand better the biological effects of this kind of exercises, probably due to neuroendrocrine responses.
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    • "The exercises in the whole body due to the exposition to energy as vibrations (whole body vibrations exercise—WBV) generated in oscillating/vibratory platform that is transferred to a subject that is in direct contact with the platform seem to bring various benefits [28] [29] [30]. There are various devices of platforms that can be used to transfer energy when the individual, in general, is with the feet on the teeterboard of the platform. "
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    ABSTRACT: Vibrations produced in oscillating/vibratory platform generate whole body vibration (WBV) exercises, which are important in sports, as well as in treating diseases, promoting rehabilitation, and improving the quality of life.WBV exercises relevantly increase themuscle strength,muscle power, and the bone mineral density, aswell as improving the postural control, the balance, and the gait. An important number of publications are found in the PubMed database with the keyword “flexibility” and eight of the analyzed papers involving WBV and flexibility reached a level of evidence II. The biggest distance between the third finger of the hand to the floor (DBTFF) of a patient with metabolic syndrome (MS) was found before the first session and was considered to be 100%. The percentages to the other measurements in the different sessions were determined to be related to the 100%. It is possible to see an immediate improvement after each session with a decrease of the %DBTFF. As the presence of MS is associated with poorer physical performance, a simple and safe protocol usingWBV exercises promoted an improvement of the flexibility in a patient with MS.
    09/2014; 2014:1-10. DOI:10.1155/2014/628518
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    • "Thus in the case of DMD, where high-intensity loads may be injurious to the inherently fragile muscle, utilizing low-intensity loads more often may be a reasonable approach to maintain bone health. Low intensity (i.e., ≤1.0 g of acceleration), high frequency vibration applies such stimulus to bone and has been shown to initiate an anabolic bone response [17], slow bone loss [18] [19], and improve bone mechanical properties [20]. Specifically, vibration has prevented bone loss associated with bed rest [21], as well as improved skeletal health in disabled children [22]. "
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    ABSTRACT: The objective of the study was to determine if low intensity, high frequency vibration training impacted the musculoskeletal system in a mouse model of Duchenne muscular dystrophy, relative to healthy mice. Three-week old wildtype (n = 26) and mdx mice (n = 22) were randomized to non-vibrated or vibrated (45 Hz and 0.6 g, 15 min/d, 5 d/wk) groups. In vivo and ex vivo contractile function of the anterior crural and extensor digitorum longus muscles, respectively, were assessed following 8 wks of vibration. Mdx mice were injected 5 and 1 days prior to sacrifice with Calcein and Xylenol, respectively. Muscles were prepared for histological and triglyceride analyses and subcutaneous and visceral fat pads were excised and weighed. Tibial bones were dissected and analyzed by micro-computed tomography for trabecular morphometry at the metaphysis, and cortical geometry and density at the mid-diaphysis. Three-point bending tests were used to assess cortical bone mechanical properties and a subset of tibiae was processed for dynamic histomorphometry. Vibration training for 8 wks did not alter trabecular morphometry, dynamic histomorphometry, cortical geometry, or mechanical properties (P≥0.34). Vibration did not alter any measure of muscle contractile function (P≥0.12); however the preservation of muscle function and morphology in mdx mice indicates vibration is not deleterious to muscle lacking dystrophin. Vibrated mice had smaller subcutaneous fat pads (P = 0.03) and higher intramuscular triglyceride concentrations (P = 0.03). These data suggest that vibration training at 45 Hz and 0.6 g did not significantly impact the tibial bone and the surrounding musculature, but may influence fat distribution in mice.
    PLoS ONE 08/2014; 9(8):e104339. DOI:10.1371/journal.pone.0104339 · 3.23 Impact Factor
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