The electrochemiluminescence (ECL) of luminol on indium tin oxide (ITO) glass was high even under a low potential around 0.4–0.5 V, which was quite different from other electrodes such as platinum. ITO nanoparticles were synthesized and used in the research on ITO glass in the ECL process. A static interaction between ITO and luminol is confirmed from UV–vis and fluorescence spectra. Then the ECL enhancement can be supposed to originate from the adsorption of luminol on ITO, which facilitated luminol’s oxidization to the excited state, giving out ECL. On the other hand, ITO can catalyze the generation of reactive oxygen species (ROSs), similar to some other nanomaterials, which also favored the ECL enhancement of luminol.
"In order to solve these questions, we have developed hereafter three new microsystems which derive from previous prototypes  based on ITO (Indium Tin Oxide) materials. Indeed, among the different materials of electrodes used for electrochemical detections, ITO became very popular due to its ability for optical (transparency)   and electrochemical (conductivity) recordings   . In order to preserve future optical applications, ITO has been considered here. "
[Show abstract][Hide abstract] ABSTRACT: The microfabrication and successful testing of a series of three ITO (Indium Tin Oxide) microsystems for amperometric detection of cells exocytosis are reported. These microdevices have been optimized in order to simultaneously (i) enhance signal-to-noise ratios, as required electrochemical monitoring, by defining appropriate electrodes geometry and size, and (ii) provide surface conditions which allow cells to be cultured over during one or two days, through apposite deposition of a collagen film. The intrinsic electrochemical quality of the microdevices as well as the effect of different collagen treatments were assessed by investigating the voltammetric responses of two classical redox systems, Ru(NH(3))(6)(3+/2+) and Fe(CN)(6)(3-/4-). This established that a moderate collagen treatment does not incur any significant alteration of voltammetric responses or degradation of the excellent signal-to-noise ratio. Among these three microdevices, the most versatile one involved a configuration in which the ITO microelectrodes were delimited by a microchannel coiled into a spiral. Though providing extremely good electrochemical responses this specific design allowed proper seeding and culture of cells permitting either single cell or cell cluster stimulation and analysis.
[Show abstract][Hide abstract] ABSTRACT: We report a novel and facile electrodeposition method to fabricate a nano-structure film of the unsubstituted metal phthalocyanine on a glassy carbon electrode (GCE). In this electrodeposition system, unsubstituted iron(II) phthalocyanine (u-FePc) was chosen as the model complex of the unsubstituted metalphthalocyanine, and the ionic liquid 1-octyl-3-methylimidazolium trifluoroacetate was employed as the solvent and electrolyte, thus avoiding the use of additional costly supporting electrolyte. Excellent electrocatalytic performance of the u-FePc nano-structure film was first evaluated by electrocatalytic oxidation of ascorbic acid (AA). Compared with the bare GCE, the oxidation peak potential of AA at u-FePc/GCE shifted negatively about 264 mV, and the oxidation peak current increased about 1.8 times. Furthermore, the as-prepared film was employed for the investigation of luminol electrochemiluminescence (ECL) behavior in neutral solution, which showed excellent performance including under selected experimental conditions, the ECL intensity showing an acceptable linear relationship for luminol concentrations between 5 × 10(-8) and 5 × 10(-6) M, and a linear response to H(2)O(2) over a wide concentration range, from 1.0 × 10(-8) to 1.0 × 10(-5) M in 3.0 μM luminol solution.
The Analyst 08/2011; 136(20):4344-9. DOI:10.1039/c1an15476a · 4.11 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: A significant phenomenon is observed when indium tin oxide (ITO) glass is used as the anode in electrochemical studies. Notable luminescent signals are observed when a pulse potential is applied to an ITO electrode in alkaline solution in the absence of a luminescent reagent. This paper discusses the mechanism of this luminescence effect in detail. The investigation reveals that the reactive oxygen species (ROSs) generated during the electrolysis are O2−, OH and H2O2. It was also found that the singlet oxygen (1O2) produced subsequently acted as the indispensable light-emitting entity and the ITO was a critical intensification determinant.
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