Risk factors in siblings of people with premature coronary heart disease

The Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Journal of the American College of Cardiology (Impact Factor: 16.5). 12/1988; 12(5):1273-1280. DOI: 10.1016/0735-1097(88)92611-3


Prior studies of the contribution of coronary disease risk factors to familial aggregation of premature coronary disease may have underestimated risk factors by relying on self-reported risk factor prevalence levels or, when risk factors have been measured, by using cut points in excess of the 90th percentile. To determine the actual prevalence of hyperlipidemia, hypertension and diabetes, and the awareness of these coronary risk factors in unaffected family members, 150 apparently coronary disease-free siblings of 86 people who had documented coronary disease before 60 years of age were studied. All subjects participated in a 1 day screening preceded by a self-administered risk factor questionnaire and a personal interview. Participation of both the index patients and siblings exceeded 86%.

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