Uterine activity in cows during the oestrous cycle, after ovariectomy and following exogenous oestradiol and progesterone

Abstract

Uterine activity was monitored in three, 2-year-old nulliparous Ayrshire heifers using intrauterine balloon-tipped catheters and pressure transducers during the oestrous cycle, after ovariectomy and following the intravenous infusion of progesterone and oestradiol-17β. During the oestrous cycle uterine activity, as measured by the frequency and amplitude of contractions, was greatest around oestrus and declined during the luteal phase of the cycle; there was a close correlation with peripheral progesterone concentrations.In two animals after bilateral ovariectomy spontaneous uterine activity persisted, whilst in the third animal the uterus was quiescent. In the first two heifers intravenous progesterone infusions reduced the spontaneous uterine activity, eventually completely abolishing it. There was evidence of a dose response effect at the two infusion rates. Oestradiol benzoate infusions initially inhibited spontaneous uterine activity before stimulating contractions with some evidence of a dose relationship.As demonstrated in normal cyclical and steroid-infused animals, uterine activity appears to be under the influence of both hormones although the influence of progesterone is greater.