Article

Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4

{ "0" : "Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street/LRB822, Worcester, MA 01605, USA" , "2" : "Mary Ellen Lane, Alexander P Runko, Nicole M Roy, Charles G Sagerström"}
Mechanisms of Development DOI:10.1016/S0925-4773(03)00114-X

ABSTRACT We report the expression of zebrafish lmo4 during the first 48 h of development. Like its murine ortholog, lmo4 is expressed in somitic mesoderm, branchial arches, otic vesicles, and limb (pectoral fin) buds. In addition, however, we report zebrafish lmo4 expression in the developing eye, cardiovascular tissue, and the neural plate and telencephalon. We demonstrate that expression in the rostral hindbrain requires acerebellar (ace/fgf8) and spielohnegrenzen (spg/pou2) activity.

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Keywords

acerebellar
 
branchial arches
 
cardiovascular tissue
 
developing eye
 
first 48 h
 
murine ortholog
 
neural plate
 
pectoral fin
 
rostral hindbrain
 

Mary Ellen Lane