Celik I, Gallicchio L, Boyd K, et al. Arsenic in drinking water and lung cancer: a systematic review

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, USA
Environmental Research (Impact Factor: 4.37). 09/2008; 108(1):48-55. DOI: 10.1016/j.envres.2008.04.001


Exposure to inorganic arsenic via drinking water is a growing public health concern. We conducted a systematic review of the literature examining the association between arsenic in drinking water and the risk of lung cancer in humans. Towards this aim, we searched electronic databases for articles published through April 2006. Nine ecological studies, two case–control studies, and six cohort studies were identified. The majority of the studies were conducted in areas of high arsenic exposure (100 μg/L) such as southwestern Taiwan, the Niigata Prefecture, Japan, and Northern Chile. Most of the studies reported markedly higher risks of lung cancer mortality or incidence in high arsenic areas compared to the general population or a low arsenic exposed reference group. The quality assessment showed that, among the studies identified, only four assessed arsenic exposure at the individual level. Further, only one of the ecological studies presented results adjusted for potential confounders other than age; of the cohort and case–control studies, only one-half adjusted for cigarette smoking status in the analysis. Despite these methodologic limitations, the consistent observation of strong, statistically significant associations from different study designs carried out in different regions provide support for a causal association between ingesting drinking water with high concentrations of arsenic and lung cancer. The lung cancer risk at lower exposure concentrations remains uncertain.

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Available from: Ismail Celik, Feb 18, 2014
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    • "Arsenic in the present times has become one of the most important global environmental toxicant which has caused health hazards to human population through its contamination in ground drinking water with inorganic arsenic [1]. "
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    ABSTRACT: Arsenic is present in the environment and human all over the world are exposed to small amounts, mostly through food, water, and air. In the developing countries like Bangladesh and India, the high prevalence of contamination, the isolation and poverty of the rural population and the high cost and complexity of arsenic removal systems have imposed a programmatic and policy challenge on an unprecedented scale. Although in India, Arsenic poisoning in ground water in Gangetic basin especially the districts adjoining the river Ganges right from Eastern Uttar Pradesh, Bihar to West Bengal is the major problem of concern. Due to which, major health related problems are arising in the population.To combat the present problem, a pre-clinical study was done on Charles foster rats and sodium arsenite at the dose of 8 mg Kg-1 body weight per day was administered to these rats for 60 days and upon these arsenic pretreated rats, novel plant extracts of Withania somnifera and Pteris longifolia were administered for 45 days to study the antidote effects of these plant extracts. These plants not only eliminated the toxic effects of arsenic but also reversed the normal physiological activity in the animal. Thus, the present study concludes that these novel plants possesses the best bioremedial impact against arsenic induced toxicity.
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    • "Arsenic is a carcinogenic element known for its poisonous characteristics which is regarded as one of the most critical environmental threats of the world for millions of people (Celik et al., 2008; Ravenscroft et al., 2009). Arsenic is a naturally existing element and its presence in food proves that it is usually accumulated from the environment (Roychowdhury et al., 2002). "
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    ABSTRACT: Yabanli, M., S. Tay & D. Giannetto, 2015. Human health risk assessment from arsenic exposure after sea bream (Sparus aurata) consumption in Aegean region, Turkey. Bulg. J. Vet. Med. (online first). The aim of the present study was to determine the amount of arsenic in the muscular tissues of wild sea breams, sea breams cultured in soil ponds and sea breams cultured in offshore marine cage systems in the Aegean Region of Turkey. Then an estimated daily intake (EDI) and target hazard quotient (THQ) based risk assessment by sea bream consumption in terms of arsenic was performed for both children and adults. The arsenic concentrations in the muscular tissues of fish were detected by inductively coupled plasma-mass spectrometry method after digestion by microwave wet burning. According to the results obtained, the highest average arsenic concentration was found in sea bream cultured in soil pond while the lowest was determined in off shore marine cultured sea bream. The arsenic concentrations determined in all fish groups were found out to be below 1 mg.kg –1 wet weight which is the international legal limit. Also the EDI values determined for children and adults were lower than 0.30 µg/kg/day, the oral reference doses (RfDo) value for arsenic and THQ value was found out to be lower than the value assessed as potentially carcinogenic. Summarising, the results of this study do not underline any potential risk in term of arsenic deriving from consumption of sea bream cultured and caught in Aegean Sea.
    Bulgarian Journal of Veterinary Medicine 01/2015; DOI:10.15547/bjvm.905
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    • "As a potential biomarker of cancer risk, telomere length may be influenced by cancer-causing agents, such as arsenic. Exposure to inorganic arsenic through contaminated drinking water affects 4100 million people worldwide (Ravenscroft et al., 2009), and chronic exposure to high levels (e.g., 4300 μg/L in drinking water ) shows clear association with increased risk for cancers of the lung (Celik et al., 2008), bladder (Mink et al., 2008), liver (Liu and Waalkes, 2008), skin (Yu et al., 2006), and kidney (Chen et al., 1992; Yuan et al., 2010). The mechanisms by which arsenic contributes to carcinogenesis are not entirely understood. "
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    ABSTRACT: Inorganic arsenic is a carcinogen whose mode of action may involve telomere dysfunction. Recent epidemiological studies suggest that chronic arsenic exposure is associated with longer telomeres and altered expression of telomere-related genes in peripheral blood. In this study, we evaluated the association of urinary arsenic concentration with expression of telomere-related genes and telomere length in Bangladeshi individuals with a wide range of arsenic exposure through naturally contaminated drinking water. We used linear regression models to estimate associations between urinary arsenic and array-based expression measures for 69 telomere related genes using mononuclear cell RNA samples from 1799 individuals. Association between arsenic exposure and a qPCR-based telomere length measure was assessed among 167 individuals. Urinary arsenic was possitively associated with expression of WRN, and negatively associated with TERF2, DKC1, TERF2IP and OBFC1 (all P<0.00035, Bonferroni-corrected threshold). We detected interaction between urinary arsenic and arsenic metabolism efficiency in relation to expression of WRN (P for interaction =0.00008). In addition, we observed that very high arsenic exposure was associated with longer telomeres compared to very low exposure (P=0.02). Our findings suggest that arsenic's carcinogenic mode of action may involve alteration of telomere maintenance and/or telomere damage. This study extends our knowledge regarding the effect of arsenic on telomere length and expression of telomere-related genes. Copyright © 2014 Elsevier Inc. All rights reserved.
    Environmental Research 11/2014; 136C:462-469. DOI:10.1016/j.envres.2014.09.040 · 4.37 Impact Factor
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