Article

Chromosomal Arrangement of AHL-Driven Quorum Sensing Circuits in Pseudomonas

ISRN Microbiology 09/2011;

ABSTRACT Pseudomonas spp. are able to colonize a large variety of environments due to their wide adaptability which is also associated with an N-acyl homoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). In this article we present a systematic overview of the genomic arrangement patterns of quorum sensing genes found in Pseudomonas and compare the topologies with those found in other bacterial genomes. We find that the topological arrangement of QS genes is more variable than previously thought but there are a few unifying features that occur in many of the topological arrangements. We hypothesize that the negative regulators of QS that are often found between the canonical luxR/ and luxI-family genes may be crucial for stabilizing the output of QS circuits.

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Keywords

able
 
bacterial genomes
 
canonical luxR/
 
environments
 
genomic arrangement patterns
 
N-acyl homoserine lactone
 
negative regulators
 
Pseudomonas
 
Pseudomonas spp
 
quorum
 
systematic overview
 
topological arrangement
 
topological arrangements
 
topologies
 
unifying features
 
wide adaptability