In-vivo Antidiabetic activity of Alcoholic and Aqueous Extract of Nymphaea lotus in Rat Model

Inventi Rapid: Ethnopharmacology 03/2011; 2011(3).

ABSTRACT The hypoglycemic activity of the ethanolic extract was evaluated in alloxan induced
diabetic rats by single dose of 100mg/kg body weight. Antihyperglycemic activity of the
extract was also evaluated at the same dose levels in alloxan monohydrate (80mg/kg s.c.)
induced diabetic rats during a 15 days treatment period. Glibenclamide (4.5mg/kg) was used
as the reference drug. Fasting blood glucose and sarum parameters triglycerides, total
cholesterol, HDL cholesterol levels were measured acute oral toxicity of theNymphaea
lotus rhizome extract was carried out in swiss albino mice. In diabetic rats, ethanolic extract
showed a significant (P<0.05) decreased the blood glucose level in a dose dependent manner
during the 15 days of the treatment period. In the acute oral toxicity study, Nymphaea
lotus showed no mortality. The present investigation shows that Nymphaea lotus rhizome has
potential anti diabetic effects.

Download full-text


Available from: Arshed Iqbal Dar, Mar 14, 2015
70 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: We have presented and reviewed evidence for the heterogeneous nature of diabetes mellitus in terms of genetics, environmental factors, insulin responses to glucose and vascular disease. We have reviewed evidence for heterogeneity between juvenile-onset diabetes (JOD) and maturity-onset diabetes (MOD) and maturity-onset diabetes of young (MODY) and for heterogeneity within groups of JOD and MOD and MODY patients. Although much remains to be learned, a beginning has been made and suggests that primary diabetes mellitus is not a single specific disease but a syndrome comprised of a variety of diseases all characterized by hyperglycemia and tissue changes that result from heterogeneous etiologic and pathogenetic factors. Future classifications of primary diabetes mellitus will undoubtedly be lengthy, as are for other diseases and syndromes also caused by a variety of etiologic and pathogenetic mechanisms.
    Schweizerische medizinische Wochenschrift 01/1980; 109(46):1774-85. · 2.09 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to investigate the hypoglycemic effect of Elaeocarpus grandiflorus water extract in alloxan-induced diabetic rats. Chronic effects of the extract on plasma glucose, lipids, blood biochemistry, some drug-metabolizing enzymes and internal organ weights were also studied. Diabetes was induced in Wistar rats by subcutaneous injection of alloxan. After being confirmed as diabetic, the animals were orally administered with distilled water or the extract at 0.0001, 0.001 or 0.01 g/kg body weight (BW) daily for 30 days. The results showed that hypoglycemic effect of the extract was dose-dependently observed on day 7. The glucose lowering effect was also continuously observed at the highest dose until the second week. The diabetic rats treated with the extract at 0.0001 and 0.001 g/kg BW possessed greater alanine aminotransferase (ALT) activity than the diabetic control rats. The diabetic rats treated with the extract at 0.001 g/kg BW possessed increased plasma triglyceride compared with the diabetic control rats. The diabetic control rats tended to possess decreased aminopyrine-N-demethylase (APD) activity. Insulin or the extract could not reverse the enzyme activity to the baseline value. However, the aniline hydroxylase (AH) activities were unchanged in all groups. The diabetic-induced BW lost was minimized by the extract. Studies for long-term effects of the extract on internal organ weights revealed that the normal rats treated with extract at 0.01 g/kg BW possessed increased weights of heart and pancreas. The extract at 0.001 g/kg BW significantly reduced the diabetic effect on the kidney and liver weights but failed to return them to the baseline values. The extract at 0.01 g/kg BW significantly reversed the heart and lung weights to the normal values. It is concluded that E. grandiflorus water extract possesses a hypoglycemic effect. The use of the extract should not be longer than two consecutive weeks. A close follow-up for any possible toxicity should be performed during the chronic use of E. grandiflorus.
  • Journal of Pharmaceutical Sciences 03/1966; 55(3):225 - 276. DOI:10.1002/jps.2600550302 · 2.59 Impact Factor