Role of Cytokines in the Pathogenesis of Anemia of Chronic Disease in Rheumatoid Arthritis
ABSTRACT The aim of our study was to evaluate the role of proinflammatory cytokines: tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and interleukin-6 (IL-6), as well as the possible contribution of interleukin-10 (IL-10) in anemia of chronic disease (ACD) of rheumatoid arthritis (RA) patients. We measured the serum levels of TNFα, IL-1β, and IL-6 in 105 anemic and 127 nonanemic RA patients. We also investigated the effects of the above cytokines on the development of burst-forming units–erythroid (BFUe) and colony-forming units–erythroid (CFUe) in bone marrow cultures. Anemic patients had significantly higher serum levels of TNFα, IL-1β, and IL-6 compared to nonanemics. Serum IL-10 levels were low and there was no significant difference in IL-10 concentrations between anemic and nonanemic patients. Proinflammatory cytokines inhibited proliferation of BFUe and CFUe. IL-10 did not decrease the erythroid colony growth. Proinflammatory cytokines may play a role in the pathogenesis of ACD in RA patients. Low levels of IL-10 possibly contribute to the development of ACD.
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ABSTRACT: Red cell distribution width (RDW) has been recognized as a novel marker for several cardiovascular diseases. The aim of this study was to evaluate the association between RDW levels and the presence of isolated coronary artery ectasia (CAE). We studied 414 subjects including 113 patients with isolated CAE (Group A), 144 patients with coronary artery disease (CAD, group B) and 157 angiographically normal controls (group C). Baseline clinical characteristics and laboratory findings including RDW were compared among three groups. The levels of RDW were significantly higher in group A and B compared with that in group C (12.97 +/- 1.4 and 12.88 +/- 1.0 vs 12.34 +/- 0.9, p = 0.020) while no difference was found between CAE and CAD (p = 0.17). Additionally, the levels of CRP were also higher in patients with CAE and CAD compared with normal controls (0.26 +/- 0.14 mg/L, 0.31 +/- 0.27 mg/L vs 0.20 +/- 0.06 mg/L, p = 0.04). The multivariate analysis indicated that RDW and CRP were the independent variables most strongly associated with the presence of isolated CAE and CAD. There was a positive correlation between levels of RDW and CRP in patients with isolated CAE (gamma=0.532, p = 0.001). Our data suggested that RDW may be a useful marker and independent predictor for the presence of isolated CAE.Journal of Translational Medicine 03/2014; 12(1):62. DOI:10.1186/1479-5876-12-62 · 3.99 Impact Factor
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ABSTRACT: A 66-year-old man with primary hyperparathyroidism (PHPT) and monoclonal gammapathy associated to it of uncertain significance (MGUS). A possible pathogenic relationship between HPTP and MGUS is analyzed. Interleukin 6 could play a pivotal role.Acta médica colombiana: AMC: organo de la Asociación Columbiana de Medicina Interna 12/2007; 32(4):219-222.
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ABSTRACT: The treatment of the infection is still challenging in children with severe malnutrition and immunosupression. Objective: evaluate and compare inflammatory markers such as C–reactive protein (CRP) and proinflammatory cytokines in children with severe malnutrition and anemia. Methodology: levels of hemoglobin, transferrin, CRP and inflammatory markers such as cytokines IL–8, IL–1β, IL–6, IL–10, TNF–α and IL–12p70 were assessed in a group of 40 children, nutritional status was also evaluated.10 were classified with marasmus, 10 with kwashiorkor, 10 well nourish with anemia and 10 well nourish with no anemia. Results: C–reactive protein was significantly higher in undernourishment children than in well nourish children. Levels of proinflammatory cytokines were higher in children with kwashiorkor along by well nourish children with anemia, children with marasmus and well nourish children with no anemia. Hemoglobin was no correlated with levels of IL–8 (r=–0,409 p=0,009), IL–6 (r=–0,442 p=0,004) and IL–10 (r=–0,436 p=0,005). Conclusion:< malnourished children could develop an inflammatory condition presenting high levels of inflammatory markers such as C–reactive protein (CRP) and proinflammatory cytokines. These results suggest that proinflammatory cytokines may participate in the pathogenesis of anemia in malnourished or well nourished patients.12/2008; 10(2):131-142.