Article

Effects of exposure to a contaminated-sediment extract on the metabolism and disposition of 17β-estradiol in english sole (Parophrys vetulus)

Environmental Conservation Division, Northwest Fisheries Center, National Marine Fisheries Service, National Oceanic & Atmospheric Administration, 2725 Montlake Boulevard East Seattle, Washington 98112 U.S.A. [Telephone: (206) 442-4638; Fax (206) 442-2359]
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology DOI:10.1016/0742-8413(91)90104-2

ABSTRACT 1. Effects of a contaminated sediment extract on the disposition and metabolism of 3H-17β-estradiol in juvenile English sole and on plasma levels of endogenous estradiol in gravid females were examined.2. Plasma estradiol levels were reduced in both extract-treated juvenile and gravid sole compared to controls, and in juvenile sole this decrease preceeded an increase in bile levels of 3H-17β-estradiol.3. Extract treatment had no significant effect on types or proportions of 17β-estradiol metabolites or levels of related hepatic enzymes.4. Thus, lower plasma estradiol levels in extract-treated sole were apparently due to alterations in physiological factors (e.g. increased bile flow) and not to enhanced metabolism of 17β-estradiol.

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Keywords

17β-estradiol
 
17β-estradiol metabolites
 
3H-17β-estradiol
 
3H-17β-estradiol.3. Extract treatment
 
bile levels
 
contaminated sediment
 
decrease preceeded
 
endogenous estradiol
 
extract-treated juvenile
 
extract-treated sole
 
hepatic enzymes.4
 
lower plasma estradiol levels
 
physiological factors
 
plasma levels
 
significant effect
 

John E Stein