Effects of exposure to a contaminated-sediment extract on the metabolism and disposition of 17β-estradiol in english sole (Parophrys vetulus)
ABSTRACT 1. Effects of a contaminated sediment extract on the disposition and metabolism of 3H-17β-estradiol in juvenile English sole and on plasma levels of endogenous estradiol in gravid females were examined.2. Plasma estradiol levels were reduced in both extract-treated juvenile and gravid sole compared to controls, and in juvenile sole this decrease preceeded an increase in bile levels of 3H-17β-estradiol.3. Extract treatment had no significant effect on types or proportions of 17β-estradiol metabolites or levels of related hepatic enzymes.4. Thus, lower plasma estradiol levels in extract-treated sole were apparently due to alterations in physiological factors (e.g. increased bile flow) and not to enhanced metabolism of 17β-estradiol.