Article

Modulation of the blood-stimulating effect of immobilized granulocyte colony-stimulating factor by immobilized hyaluronidase.

Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
Bulletin of Experimental Biology and Medicine (impact factor: 0.27). 07/2011; 151(3):324-9. pp.324-9
Source: PubMed

ABSTRACT We evaluated whether immobilized hyaluronidase can modify the hematotropic effect of immobilized granulocyte CSF (G-CSF). The preparation of immobilized hyaluronidase (50 arb. units per mouse) potentiated the specific effect of immobilized G-CSF on granulomonocytopoiesis. The preparation was shown to facilitate the indirect effect of immobilized G-CSF on hemopoiesis (stimulation of the erythroid and lymphoid hemopoietic stems). These changes were accompanied by an increase in functional activity of hemopoietic precursor cells, secretion of humoral factors by bone marrow myelokaryocytes, and concentration of hemopoietins in the serum.

0 0
 · 
0 Bookmarks
 · 
14 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

erythroid
 
functional activity
 
G-CSF
 
hemopoiesis
 
hemopoietic precursor cells
 
humoral factors
 
immobilized G-CSF
 
immobilized granulocyte CSF
 
immobilized hyaluronidase
 
indirect effect
 
lymphoid hemopoietic stems
 
units