Article

Hemophagocytic lymphohistiocytosis in a rheumatoid arthritis patient treated with infliximab.

Division of Hematology, Clinical Immunology and Nephrology, Matsue Red Cross Hospital, Japan.
Internal Medicine (impact factor: 0.94). 01/2012; 51(6):655-7. pp.655-7
Source: PubMed

ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a rare condition with high mortality. We report a case of a 74-year-old woman with rheumatoid arthritis who developed HLH secondary to pyelonephritis due to Escherichia coli infection following infliximab treatment. Bone marrow aspiration showed proliferation of histiocytes with hemophagocytosis. The patient died despite treatment with intravenous antibiotics intravenous methylprednisolone and intravenous immunoglobulin. Cytokine levels were measured and are discussed.

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Keywords

74-year-old woman
 
Bone marrow aspiration
 
Escherichia coli infection
 
Hemophagocytic lymphohistiocytosis
 
histiocytes
 
HLH
 
HLH secondary
 
intravenous antibiotics intravenous methylprednisolone
 
rare condition
 

Yuzo Oda