Article

Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nature Neuroscience (Impact Factor: 14.98). 03/2012; 15(5):700-2. DOI: 10.1038/nn.3079
Source: PubMed

ABSTRACT Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.

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