Signaling-mediated control of ubiquitin ligases in endocytosis

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy.
BMC Biology (Impact Factor: 7.43). 03/2012; 10:25. DOI: 10.1186/1741-7007-10-25
Source: PubMed

ABSTRACT Ubiquitin-dependent regulation of endocytosis plays an important part in the control of signal transduction, and a critical issue in the understanding of signal transduction therefore relates to regulation of ubiquitination in the endocytic pathway. We discuss here what is known of the mechanisms by which signaling controls the activity of the ubiquitin ligases that specifically recognize the targets of ubiquitination on the endocytic pathway, and suggest alternative mechanisms that deserve experimental investigation.

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