Chapter

Phytochemical Studies of Fractions and Compounds Present in Vernonanthura Patens with Antifungal Bioactivity and Potential as Antineoplastic

In book: Phytochemicals - A Global Perspective of Their Role in Nutrition and Health
Source: InTech
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    ABSTRACT: Antibacterial and molluscicidal activities of methanol and chloroform extracts of 16 plant species belonging to the families Compositae and Melastomataceae were evaluated. The chloroform extract of Vernonanthura tweediana and the methanol extract of Senecio santelisis resulted to be very toxic to brine shrimp nauplii (LC(50)=1 microg/ml). Chloroform extracts of S. santelisis and Senecio leucostachys as well as the methanol extract of Wedelia subvaginata displayed molluscicidal effects on Biomphalaria peregrina showing LC(100)<100 microg/ml. Moderate antibacterial action was produced by the chloroform extracts of Flaveria bidentis, Grindelia scorzonerifolia and Vernonia incana against two strains of Staphylococcus aureus.
    Fitoterapia 04/2007; 78(3):227-31. DOI:10.1016/j.fitote.2006.11.005 · 2.22 Impact Factor
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    08/2005; 39(2).
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    ABSTRACT: Ethanol extracts of leaves of Ficus septica Burm and Sterculia foetida L. were examined for their antibacterial, antifungal, antiprotozoal, and cytotoxic properties. To determine these activities, the extracts were tested against bacteria and fungus through disc diffusion assay; against protozoa through growth curve determination, antiprotozoal and cytotoxicity assays. The extracts revealed antibacterial activities, inhibiting the growth of Staphylococcus aureus and Escherichia coli. Antifungal assay for F. septica extract showed that it inhibited Candida albicans. The antiprotozoal assay against Trichomonas vaginalis showed that F. septica can reduce the number of parasites. Moreover, antiprotozoal assays against Entamoeba histolytica revealed that F. septica and S. foetida can inhibit the growth of the parasites, wherein the action can be comparable to metronidazole. With the in situ cell death detection kit, T. vaginalis exposed to F. septica and E. histolytica exposed to F. septica and S. foetida were observed to fluoresce in red surrounded by a yellow signal signifying apoptotic-like changes. Preliminary phytochemical screening revealed the chemical composition of F. septica extracts containing alkaloids, quaternary base, tannins, 2-deoxysugars, and benzopyrone nucleus, while S. foetida possessing tannins, 2-deoxysugars, leucoanthocyanin, and benzopyrone nucleus. Thus, these plant extracts can possibly be used to produce alternative forms of antimicrobials.

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