Cancer Gene Therapy- Developments and Future Perspectives

06/2011; ISBN: 978-953-307-617-1 In book: Gene Therapy - Developments and Future Perspectives
Source: InTech
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    ABSTRACT: Lung cancer patients suffer a 15% overall survival despite advances in chemotherapy, radiation therapy, and surgery due to the usual finding of advanced disease at diagnosis. Attempts to improve survival in advanced disease using various combinations of chemotherapy have demonstrated that no regimen is superior, suggesting a therapeutic plateau and the need for novel, more specific, and less toxic therapeutic strategies. Techniques have been developed that allow transfer of functional genes into mammalian cells, such as those that block activated tumor-promoting oncogenes and/or those that replace inactivated tumor-suppressing or apoptosis-promoting genes. This article will discuss the therapeutic implications of these molecular changes associated with bronchogenic carcinomas, and will then review the status of gene therapies for treatment of lung cancer.
    Thoracic Surgery Clinics 12/2006; 16(4):397-419, vii.
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    ABSTRACT: Vascular glioblastomas become liquefied when contaminated with spores of the non-pathogenic Clostridium butyricum M 55. The spores are administered by intracarotid injection. The oncolysis is complete one week after injection. The glioblastoma is converted into a brain abscess which is then operated on appropriately. Forty nine patients have been treated in this manner. The rate of recurrence, however, remained uninfluenced.
    Acta Neurochirurgica 02/1978; 42(1-2):123-5. · 1.55 Impact Factor
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    Cancer Research 08/1955; 15(7):473-8. · 8.65 Impact Factor

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