Article

Cryptococcal osteomyelitis of the scapula and rib in an immunocompetent patient.

* Department of Infectious Diseases, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University , Shanghai.
Medical mycology: official publication of the International Society for Human and Animal Mycology (impact factor: 2.13). 03/2012; 50(7):751-5. DOI:10.3109/13693786.2012.670277 pp.751-5
Source: PubMed

ABSTRACT Cryptococcal osteomyelitis is extremely rare and almost always occurs in immunocompromised patients. We describe a case of osteomyelitis due to Cryptococcus neoformans involving both scapula and rib in an immunocompetent and previously healthy patient. The patient received treatment with amphotericin B deoxycholate and flucytosine for 4 weeks, followed by oral fluconazole 400 mg per day for 8 weeks and 200 mg per day for 9 months. The 12-month course of antifungal therapy resulted in complete clinical recovery and undetectable serum cryptococcal antigen. Cryptococcal osteomyelitis should be suspected in any immunocompetent patient with osteolytic lesions on radiological images.

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Keywords

9 months
 
amphotericin B deoxycholate
 
antifungal therapy
 
complete clinical recovery
 
Cryptococcal osteomyelitis
 
healthy patient
 
immunocompetent patient
 
immunocompromised patients
 
oral fluconazole 400 mg
 
osteolytic lesions
 
osteomyelitis
 
radiological images