Article

Human T-cell leukemia virus type 1 infection worsens prognosis of hepatitis C virus-related living donor liver transplantation.

Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Transplant International (impact factor: 2.92). 04/2012; 25(4):433-8. DOI:10.1111/j.1432-2277.2012.01434.x
Source: PubMed

ABSTRACT Severe and life-threatening donor-transmitted human T-cell leukemia virus type 1 (HTLV-1) infections after solid organ transplantation have been reported. However, in HTLV-1-infected recipients, graft and patient survival were not fully evaluated. A total of 140 patients underwent living donor liver transplantation (LDLT). Of these, 47 of 126 adult recipients showed indications of hepatitis C virus (HCV)-related liver disease. The HTLV-1 prevalence rate was 10 of 140 recipients (7.14%) and three of 140 donors (0.02%). In HCV-related LDLT, graft and patient survival was worsened by HTLV-1 infection in recipients (seven cases). The 1-, 3-, and 5-year survival rates in the HCV/HTLV-1-co-infected group were 67%, 32%, and 15%, respectively, and the corresponding rates in the HCV-mono-infected group were 80%, 67%, and 67%, respectively. Only the 5-year survival rates were statistically significant (P=0.04, log-rank method). HTLV-1 infection in recipients is also an important factor in predicting survival in HTLV-1 endemic areas.

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Keywords

126 adult recipients
 
5-year survival rates
 
cases
 
corresponding rates
 
donor liver transplantation
 
graft
 
HCV)-related liver disease
 
HCV-mono-infected group
 
HCV/HTLV-1-co-infected group
 
hepatitis C virus
 
HTLV-1 endemic areas
 
life-threatening donor-transmitted human T-cell leukemia virus type 1
 
log-rank method
 
patient survival
 
Severe
 
solid organ transplantation