Article

Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder.

Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892-2670, USA.
Progress in Neuro-Psychopharmacology and Biological Psychiatry (impact factor: 3.25). 03/2012; 38(2):127-33. DOI:10.1016/j.pnpbp.2012.02.014 pp.127-33
Source: PubMed

ABSTRACT A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD.
19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3 T scanner.
Children at familial risk for BD exhibited increased putamen activation during unsuccessful inhibition that distinguished them from both healthy and BD children. Youths with BD exhibited reduced activation of the right nucleus accumbens during unsuccessful inhibition as compared to the other participant groups.
Striatal activation patterns differ between youths at risk for BD and healthy comparison children during a motor inhibition task.

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Keywords

13 asymptomatic youths
 
19 euthymic youths
 
21 healthy comparison children
 
3 T scanner
 
BD children
 
BD exhibited
 
brain activity
 
first-degree relative
 
healthy comparison children
 
motor inhibition
 
motor inhibition task
 
neural correlates
 
neural underpinnings
 
nucleus accumbens
 
participant groups
 
putamen activation
 
stop signal task
 
Striatal activation patterns
 
symptom-free individuals
 
symptom-free youths