Article

Coronary artery disease in aging women: a menopause of endothelial progenitor cells?

Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
The Medical clinics of North America (impact factor: 2.18). 01/2012; 96(1):93-102. DOI:10.1016/j.mcna.2012.01.008 pp.93-102
Source: PubMed

ABSTRACT The cardiovascular protection provided to women during the reproductive age and the unique angiogenic properties of the female reproductive system provide insights into the complex regulatory network of female sex hormones, angiogenic growth factors, and stem cell regulatory molecules. The intricate and interwoven endometrial physiology of the female menstrual cycle shows that in order to harness the physiologic cardioprotection provided by nature to women of reproductive age, for better cardiovascular therapies in postmenopausal women and the population in general, a coherent and systematic approach is needed.

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Keywords

angiogenic growth factors
 
cardiovascular protection
 
cardiovascular therapies
 
complex regulatory network
 
female menstrual cycle
 
interwoven endometrial physiology
 
intricate
 
physiologic cardioprotection
 
systematic approach
 
unique angiogenic properties