Across-study and within-subject functional connectivity of a right temporo-parietal junction subregion involved in stimulus-context integration

Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany.
NeuroImage (Impact Factor: 6.36). 02/2012; 60(4):2389-98. DOI: 10.1016/j.neuroimage.2012.02.037
Source: PubMed

ABSTRACT Bidirectional integration between sensory stimuli and contextual framing is fundamental to action control. Stimuli may entail context-dependent actions, while temporal or spatial characteristics of a stimulus train may establish a contextual framework for upcoming stimuli. Here we aimed at identifying core areas for stimulus-context integration and delineated their functional connectivity (FC) using meta-analytic connectivity modeling (MACM) and analysis of resting-state networks. In a multi-study conjunction, consistently increased activity under higher demands on stimulus-context integration was predominantly found in the right temporo-parietal junction (TPJ), which represented the largest cluster of overlap and was thus used as the seed for the FC analyses. The conjunction between task-dependent (MACM) and task-free (resting state) FC of the right TPJ revealed a shared network comprising bilaterally inferior parietal and frontal cortices, anterior insula, premotor cortex, putamen and cerebellum, i.e., a 'ventral' action/attention network. Stronger task-dependent (vs. task-free) connectivity was observed with the pre-SMA, dorsal premotor cortex, intraparietal sulcus, basal ganglia and primary sensori motor cortex, while stronger resting-state (vs. task-dependent) connectivity was found with the dorsolateral prefrontal and medial parietal cortex. Our data provide strong evidence that the right TPJ may represent a key region for the integration of sensory stimuli and contextual frames in action control. Task-dependent associations with regions related to stimulus processing and motor responses indicate that the right TPJ may integrate 'collaterals' of sensory processing and apply (ensuing) contextual frames, most likely via modulation of preparatory loops. Given the pattern of resting-state connectivity, internal states and goal representations may provide the substrates for the contextual integration within the TPJ in the absence of a specific task.

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Available from: Svenja Caspers, Aug 25, 2015
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    • "Importantly, as experiments were defined by activation in the region of interest, the highest convergence will always be found close to the seed. Significant convergence outside the seed, in turn, then indicates functional connectivity over the included numerous experimental tasks (Eickhoff and Grefkes 2011; Jakobs et al. 2012). The key idea behind ALE is to treat the reported foci as centers for 3D Gaussian probability distributions as opposed to single points, capturing the spatial uncertainty associated with each focus. "
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    • "In order to reduce spurious correlations by confounds such as physiological noise and motion [cf. Bandettini and Bullmore, 2008], variance that could be explained by firstor second-order effects of the following nuisance variables was removed from each voxel's time series: (i) the six motion parameters derived from the image realignment, (ii) their first derivative, and (iii) global signal intensity per time-point [(Jakobs et al., 2012; Reetz et al., 2012; Satterthwaite et al., 2012, 2013b)]. Data was then bandpass filtered, preserving frequencies between 0.01 and 0.08 Hz [Fox and Raichle, 2007; zu Eulenburg et al., 2012). "
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    Human Brain Mapping 01/2015; 36(5). DOI:10.1002/hbm.22748 · 6.92 Impact Factor
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    • "One of the regions consistently showing connectivity differences across both the clustering and seed-based analyses was a portion of the TPJ. The TPJ is a functionally heterogeneous region that has been previously been implicated in attentional orienting [Cieslik et al., 2011], theory of mind [Young et al., 2010] and sensory integration [Jakobs et al., 2012]. To better understand this apparent heterogeneity, clustering of structural connectivity information has been used to divide the TPJ into three subregions , which functionally connected to regions of the default mode, salience, and frontoparietal networks, respectively [Rushworth et al., 2006]. "
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