Recent trends in antibody based sensors
ABSTRACT This review details recent advances in the fields of immunosensors and closely related immunoassays in the past decade, together with a discussion of possible future trends. Immunosensors can be classified by the way in which they transduce the signal produced upon the formation of an antibody antigen complex. Recent advancements to these methods of detection and transduction are discussed in detail, with particular focus on electrochemical, optical, piezoelectric and magnetic based sensors. The varying applications of these sensors are also discussed. Some of the most significant advances include development of immunosensors for the continuous monitoring of analytes, point of care (PoC) devices, with lower unit costs, automation, reusability and ease of use. Immunosensor technology has advanced at a prolific rate since its conception and has grown into a diverse area of ongoing research.
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ABSTRACT: The ability to detect pathogenic and physiologically relevant molecules in the body with high 22 sensitivity and specificity offers a powerful opportunity in early diagnosis and treatment of 23 diseases. Early detection and diagnosis can be used to greatly reduce the cost of patient care 24 associated with advanced stages of many diseases. However, despite their widespread clinical 25 use, these techniques have a number of potential limitations. For example, a number of 26 diagnostic devices have slow response times and are burdensome to patients. Furthermore, 27 these assays are expensive and cost the health care industry billions of dollars every year. 28 Therefore, there is a need to develop more efficient and reliable sensing and detection 29 technologies. A biosensor is commonly defined as an analytical device that uses a biological 30Journal of applied biomedicine 01/2014; 12(1). DOI:10.1016/j.jab.2013.02.001 · 1.78 Impact Factor
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ABSTRACT: The simultaneous detection of multiple biological analytes is achieved for the first time using a single optical fiber based surface plasmon resonance (SPR) biosensor. This is achieved by collecting the plasmonic wave re-scattered by a rough metallic coating deposited onto two separate sections (sensing regions) of a single multimode optical fiber. The results obtained showed that two gastric cancer biomarkers (apolipoprotein E and clusterin) are detected in clinically relevant concentrations each on a separate sensing region, simultaneously, something that cannot be done in traditional fiber based SPR biosensors that read the transmitted or reflected light to monitor the position of the resonance. While this multiplexing demonstration has been performed with two different biomarkers, it paves the way for the multiplexed detection of a larger number of biomarkers using a simple fiber optic based SPR sensor for point of decision diagnostics.Sensors and Actuators B Chemical 07/2013; 5:454-458. DOI:10.1016/j.snb.2013.03.131 · 3.84 Impact Factor
Chapter: Electroanalytical Sensor TechnologyElectrochemistry, Edited by Dr. M. Khalid, 02/2013: chapter Electroanalytical Sensor Technology (Chapter 7),: pages 38; InTech., ISBN: 978-953-51-1018-7