Selenium and human health. Lancet

Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
The Lancet (Impact Factor: 45.22). 02/2012; 379(9822):1256-68. DOI: 10.1016/S0140-6736(11)61452-9
Source: PubMed


Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone. In the past 10 years, the discovery of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance of selenoproteins to health. Low selenium status has been associated with increased risk of mortality, poor immune function, and cognitive decline. Higher selenium status or selenium supplementation has antiviral effects, is essential for successful male and female reproduction, and reduces the risk of autoimmune thyroid disease. Prospective studies have generally shown some benefit of higher selenium status on the risk of prostate, lung, colorectal, and bladder cancers, but findings from trials have been mixed, which probably emphasises the fact that supplementation will confer benefit only if intake of a nutrient is inadequate. Supplementation of people who already have adequate intake with additional selenium might increase their risk of type-2 diabetes. The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional selenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenium supplements.

60 Reads
  • Source
    • "An estimated 0.5–1 billion people worldwide have been affected by low level selenium intake [5]. Selenium deficiency may lead to increase in the risk of various pathologies including cardiovascular diseases [6]. Many recent studies indicate selenium as a nutritional food and are recommended by German and Austrian Nutrition Societies. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Alcoholic cardiomyopathy is the damage caused to the heart muscles due to high level of alcohol consumption resulting in enlargement and inflammation of the heart. Selenium is an important trace element that is beneficial to human health. Selenium protects the cells by preventing the formation of free radicals in the body. In the present study, protein mediated synthesis of SeNPs was investigated. Two different sizes of SeNPs were synthesized using BSA and keratin. The synthesized SeNPs were characterized by scanning electron microscopy (SEM) with elemental composition analysis Energy Dispersive X-ray spectroscopy(EDX) and X-ray diffraction (XRD). This study demonstrates the in vitro and in vivo antioxidative effects of sodium selenite and SeNPs. Further selenium and SeNPs were evaluated for their ability to protect against 1% ethanol induced oxidative stress in H9C2 cell line. The selenium and SeNPs were found to reduce the 1% ethanol-induced oxidative damage through scavenging intracellular reactive oxygen species. The selenium and SeNPs could also prevent pericardial edema induced ethanol treatment and reduced apoptosis and cell death in zebrafish embryos. The results indicate that selenium and SeNPs could potentially be used as an additive in alcoholic beverage industry to control the cardiomyopathy. Copyright © 2015 Elsevier GmbH. All rights reserved.
    Journal of Trace Elements in Medicine and Biology 10/2015; 32:135-144. DOI:10.1016/j.jtemb.2015.06.010 · 2.37 Impact Factor
    • "Selenium (Se) is an essential element for animals and humans. Low Se status has been associated with increased risk of mortality, impaired immune function and cognitive decline (Fairweather-Tait et al., 2011; Rayman, 2012). The Committee on the Medical Aspects of Food Policy (COMA) proposed a Reference Nutrient Intake (RNI) of 60 and 75 lg d À1 for females and males, respectively, based on a requirement of 1 lg Se kg À1 body weight d À1 (Fairweather-Tait et al., 2011). "
    [Show abstract] [Hide abstract]
    ABSTRACT: There is increasing interest in enhancing the micronutrient composition of cereals through fertilization. The aims of this study were (1) to determine the Se concentration of commercial beers retailing in the UK, and (2) to test if the transfer of Se, from biofortified grain to final beer product, is <10% under UK cultivation conditions, as seen previously under Mediterranean conditions. The Se concentration of 128 commercial beers was measured, using inductively coupled plasma-mass spectrometry (ICP-MS). The selenium content of commercial beers varied 6.5-fold, with beers originating from America having higher Se concentrations than those from Europe. Laboratory-scale brewing trials with isotopically-enriched (77)Se wheat, sampled from UK field-sites, showed that most (77)Se losses in the brewing process occurred during mashing (54%), with fermented beer containing ∼10% of the (77)Se initially present in the wheat grain. Total N values in wort and malt were positively correlated with the (77)Se content of the wheat grain. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Food Chemistry 09/2015; 182. DOI:10.1016/j.foodchem.2015.02.121 · 3.39 Impact Factor
  • Source
    • "Another set of sensitivity analyses was undertaken to focus on groups which may represent individuals with higher risk (those reporting taking a cholesterol lowering medication) or lower risk (those with selenium levels in a range previously identified as being associated with lowest mortality) of cardiovascular disease. Finally, an attempt was made to identify participants with serum selenium o122 μg/L, the level which delineated negative and positive risk for certain outcomes (cancer, non-melanoma skin cancer, type II diabetes mellitus) in the Nutritional Prevention of Cancer study (reviewed in (Rayman, 2012)). However, only 2 (unweighted) NHANES participants had serum selenium in this range, thus analysis of associations with lipids was not possible. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Selenium is an essential micronutrient, and due to its antioxidant activity, is hypothesized to be beneficial to cardiovascular health. However, the evidence for an association between selenium and health markers such as lipid levels has been mixed. This may be due to substantial variability in the level of selenium intake between populations and potential non-linearity of selenium-health outcome associations. We used the 2011-2012 National Health and Nutrition Examination Survey (NHANES) to examine the relationship between serum selenium and lipid levels among participants aged 12 years and older. Associations were evaluated using both linear regression models, as well as ordinal logistic regression and quantile regression models to allow for potential non-linear relationships. In all models, potential confounders of sex, age group, race/ethnicity, educational attainment and cotinine were included. Overall, 40% of participants had total cholesterol levels classified as borderline or elevated, and total cholesterol increased with increasing selenium (p=0.01). A similar pattern was seen for triglycerides (p=0.02). LDL cholesterol was also associated with selenium but not in a linear fashion; HDL cholesterol did not vary with selenium. Multivariate quantile regression showed significant associations between selenium and total cholesterol, LDL cholesterol, and triglycerides. The effect of selenium was stronger with increasing quantile for total cholesterol and for triglycerides. In contrast, for LDL cholesterol the association was positive in the 10th and 50th percentiles, but (non-significant and) negative in the 90th percentile. These results show that while selenium may impact cardiovascular health via effects on lipid levels, the associations may not be linear. Copyright © 2015 Elsevier Inc. All rights reserved.
    Environmental Research 07/2015; 140. DOI:10.1016/j.envres.2015.03.020 · 4.37 Impact Factor
Show more


60 Reads
Available from