Article

The variant translocation of ABL1 gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leukemia.

Department of Medical Genetics, Uludag University, Medical Faculty, Bursa, Turkey.
Bratislavske lekarske listy (impact factor: 0.4). 01/2012; 113(1):19-20. pp.19-20
Source: PubMed

ABSTRACT We present the case of the childhood ALL that was identified by the translocation of the ABL1 gene to the q21 band of chromosome 2 without t(9;22)(q34;q11) translocation. The observation of a poor clinical course of the case may contribute to explanation of the action of t(9;22)(q34;q11) translocation, of which poor prognostic action is known on ALL's, in terms of ABL1 gene, independent of the BCR gene. On the other hand, the prognostic significance of this variant ABL1 translocation detection, which is very rarely observed, will cast a light on future cases (Tab. 1, Fig. 1, Ref. 11).

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Keywords

chromosome 2
 
future cases
 
independent
 
poor clinical course
 
poor prognostic action
 
prognostic significance
 
Tab
 
terms
 

M Karkucak