Secreted miRNAs suppress atherogenesis.

Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of Medicine, 11-125 Translational Research Center, Philadelphia, Philadelphia 19104-5156, USA.
Nature Cell Biology (Impact Factor: 20.06). 02/2012; 14(3):233-5. DOI: 10.1038/ncb2452
Source: PubMed

ABSTRACT Endothelial-vascular smooth muscle cell communication has a critical role in cardiovascular homeostasis and the pathogenesis of atherosclerosis. A study now demonstrates extracellular-vesicle-mediated transfer of the atheroprotective microRNAs miR-143/145 between endothelial and vascular smooth muscle cells, providing compelling evidence that intercellular transport of miRNAs can influence a pathological process, namely atherosclerosis.

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