The Ethics of a Genetic Screening Study for Antisocial Personality Disorder With Mesoamericans Case Study in the Ethics of Mental Health Research

Hospital Nacional Rosales, San Salvador, El Salvador.
The Journal of nervous and mental disease (Impact Factor: 1.69). 03/2012; 200(3):260-4. DOI: 10.1097/NMD.0b013e318247d23e
Source: PubMed


This article contains an analysis of a research ethics committee's (REC) concerns about a study protocol involving genetic screening for antisocial personality disorder. The study was proposed by US university researchers and to be conducted with Mesoamerican populations in the United States and in their countries of origin. The analysis explains why the study was not considered ethical by the REC, pointing to issues with the choice of study population, informed consent, confidentiality, and posttrial obligations. Some recommendations are provided for ways in which the study could have been redesigned.

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Available from: Maria Virginia Rodriguez, Sep 24, 2015
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    ABSTRACT: The main public health advantages of examining gene by environment interactions (i.e., G × E) in externalizing behavior lie in the realm of personalized interventions. Nevertheless, the incorporation of genetic data in randomized controlled trials is fraught with difficulties and raises ethical questions. This paper has been written from the perspective of developmental psychologists who, as researchers, see themselves confronted with important and in part new kinds of ethical questions arising from G × E research in social sciences. The aim is to explicate and discuss ethical questions, based on the conviction that what is ethically salient in a research setting will also be relevant in that area of public healthcare incorporating research findings. The ethical questions discussed include: whether it is ethically responsible to withhold an effective treatment; to what extent genetic results should be disclosed; whether researchers should be allowed to collect genetic data of both child and parent; and what are costs and benefits of personalized interventions based on (genetic) screening. We made an attempt to address these questions, but it is up to researchers to determine whether the solutions are suitable for their G × E research in social sciences.
    Public Health Ethics 09/2015; DOI:10.1093/phe/phv024 · 1.18 Impact Factor