Typical carcinoid arising in mature teratoma of anterior mediastinum.
ABSTRACT Teratoma is the second most common mediastinal neoplasm, but malignant transformation in mature teratomas is uncommon at both gonadal and extragonadal sites. A 35-year-old woman presented with an anterior mediastinal mass. Computed tomography suggested a teratoma. Meticulous pathological examination helped in detecting a neuroendocrine neoplasm (carcinoid) within the mature teratoma. Malignant transformation in a teratoma is difficult to diagnose on clinical and radiological assessment; histopathology is essential to detect the malignant nature of these neoplasms.
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ABSTRACT: A 36-year-old woman had presented with dry cough for 2 months. Thoracic computed tomography (CT) scan showed a 12 cm × 8 cm ×5 cm mass in the anterior mediastinum. Due to intimately involving the aortic arch, tumor was removed incompletely. Residual tumor remained approximate 2 cm × 3 cm × 4 cm. Histologic diagnosis was a mature cystic teratoma containing a carcinoid. Subsequently, radiotherapy (RT) was administrated on residual tumor for a total dose of 50 Gy at 2 Gy/d fraction in 25 fractions. At 2-year follow-up, the patient had stable disease. In conclusion, adjuvant radiotherapy with 50 Gy is an effective approach for residual tumor of mediastinal carcinoid teratoma.04/2013; 5(2):E61-4. DOI:10.3978/j.issn.2072-1439.2012.11.11