Article
Knowledge acquisition, semantic text mining, and security risks in health and biomedical informatics.
Jingshan Huang, J Harold Pardue, School of Computer and Information Sciences, University of South Alabama, Mobile, AL 36688, United States.
World journal of biological chemistry
02/2012;
3(2):27-33.
DOI:10.4331/wjbc.v3.i2.27
pp.27-33
Source: PubMed
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Cited In (0)
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Article: Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34.
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ABSTRACT: Meningioma is a frequently occurring tumor of the meninges surrounding the central nervous system. Loss of the short arm of chromosome 1 (1p) is the second most frequent chromosomal abnormality observed in these tumors. Previously, we identified a 3.7 megabase (Mb) region of consistent deletion on 1p33-p34 in a panel of 157 tumors. Loss of this region was associated with advanced disease and predictive for tumor relapse. In this report, a high-resolution integrated map of the region was constructed (CompView) to identify all markers in the smallest region of overlapping deletion (SRO). A regional somatic cell hybrid panel was used to more precisely localize those markers identified in CompView as within or overlapping the region. Additional deletion mapping using microsatellites localized to the region narrowed the SRO to approximately 2.8 Mb. The 88 markers remaining in the SRO were used to screen genomic databases to identify large-insert clones. Clones were assembled into a physical map of the region by PCR-based, sequence-tagged site (STS) content mapping. A sequence from clones was used to validate STS content by electronic PCR and to identify transcripts. A minimal tiling path of 43 clones was constructed across the SRO. Sequence data from the most current sequence assembly were used for further validation. A total of 59 genes were ordered within the SRO. In all, 17 of these were selected as likely candidates based on annotation using Gene Ontology Consortium terms, including the MUTYH, PRDX1, FOXD2, FOXE3, PTCH2, and RAD54L genes. This annotation of a putative tumor suppressor locus provides a resource for further analysis of meningioma candidate genes.Oncogene 02/2004; 23(4):1014-20. · 6.37 Impact Factor -
Article: Computer crash--lessons from a system failure.
New England Journal of Medicine 04/2003; 348(10):881-2. · 53.30 Impact Factor
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Keywords
biological experiments
biological functions
biological research
biological systems
computational methods
Computational techniques
critical link
gain knowledge
human knowledge
knowledge acquisition
knowledge sharing
Large amounts
nontrivial transformation
paper summarizes
readers
research directions
researchers
security issues
semantic text mining techniques
traditional syntactic text mining