Perinatal BPA exposure demasculinizes males in measures of affect but has no effect on water maze learning in adulthood.
ABSTRACT Bisphenol A (BPA) is an endocrine disrupting agent that can alter the normal gonadal steroid-sensitive sexual differentiation of the brain and behavior. While reproductive behavior and physiology are known to be altered by perinatal exposure to this compound, less is known about BPA's effects on sex differences in learning and measures of affect. In order to evaluate the effects of perinatal BPA treatment on learning and affect in adulthood, we exposed rats to one of five doses of BPA through gestation and lactation then examined adult behavior in the Morris Water Maze (MWM), the Elevated Plus Maze (EPM) and the Forced Swim Test (FST). No effect of BPA was observed in the MWM, but on both the EPM and FST, low doses (5 μg/kg) of BPA eliminated sex differences found between controls; furthermore, a non-monotonic dose-response observed in previous studies was confirmed for these tasks. Overall, our study adds to the growing data suggesting that BPA interferes with the normal development of affective behaviors in a non-linear, dose-dependent manner.
Article: Perinatal bisphenol A exposure promotes hyperactivity, lean body composition, and hormonal responses across the murine life course[show abstract] [hide abstract]
ABSTRACT: The development of adult-onset diseases is influenced by perinatal exposure to altered environ-mental conditions. One such exposure, bisphenol A (BPA), has been associated with obesity and diabetes, and consequently labeled an obesogen. Using an iso-genic murine model, we examined the effects of peri-natal exposure through maternal diet to 50 ng (n20), 50 g (n21), or 50 mg (n18) BPA/kg diet, as well as controls (n20) on offspring energy expenditure, spontaneous activity, and body composition at 3, 6, and 9 mo of age, and hormone levels at 9 and 10 mo of age. Overall, exposed females and males exhibited in-creased energy expenditure (P<0.001 and 0.001, re-spectively) throughout the life course. In females, horizontal and vertical activity increased (P0.07 and 0.06, respectively) throughout the life course. Gener-ally, body composition measures were not different throughout the life course in exposed females or males (all P>0.44), although body fat and weight decreased in exposed females at particular ages (all P<0.08). Milli-gram-exposed females had improved glucose, insulin, adiponectin, and leptin profiles (all P<0.10). Thus, life-course analysis illustrates that BPA is associated with hyperactive and lean phenotypes. Variability across studies may be attributable to differential exposure duration and timing, dietary fat and phytoestrogen content, or lack of sophisticated phenotyping across the life course.—Anderson, O. bisphenol A exposure promotes hyperactivity, lean body composition, and hormonal responses across the murine life course. FASEB J. 27, 000 – 000 (2013). www.fasebj.org Key Words: developmental origins of health and disease energy expenditure glucose insulin metabolic homeostasisThe FASEB Journal 01/2013; 27(January):1-9. · 5.71 Impact Factor