Article

Atropodiastereoselectivity in solid state BINOL synthesis: leads from the estradiol platform.

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, I-80126 Naples, Italy.
Steroids (impact factor: 2.83). 02/2012; 77(6):630-4. DOI:10.1016/j.steroids.2012.02.007
Source: PubMed

ABSTRACT A novel functionalized steroidal BINOL scaffold is produced via a remarkable sequence of dehydrogenation, chlorination and atroposelective phenolic coupling steps. Its formation is straightforwardly obtained in a one-step synthesis under solid state conditions and in the absence of chiral additives.

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Keywords

atroposelective phenolic coupling steps
 
dehydrogenation
 
novel functionalized steroidal BINOL scaffold
 
one-step synthesis
 
solid state conditions