Suboptimal magnesium status in the United States: Are the health consequences underestimated?

Center for Magnesium Education & Research, 13-1255 Malama Street, Pahoa, HI 96778, USA.
Nutrition Reviews (Impact Factor: 6.08). 03/2012; 70(3):153-64. DOI: 10.1111/j.1753-4887.2011.00465.x
Source: PubMed


In comparison with calcium, magnesium is an "orphan nutrient" that has been studied considerably less heavily. Low magnesium intakes and blood levels have been associated with type 2 diabetes, metabolic syndrome, elevated C-reactive protein, hypertension, atherosclerotic vascular disease, sudden cardiac death, osteoporosis, migraine headache, asthma, and colon cancer. Almost half (48%) of the US population consumed less than the required amount of magnesium from food in 2005-2006, and the figure was down from 56% in 2001-2002. Surveys conducted over 30 years indicate rising calcium-to-magnesium food-intake ratios among adults and the elderly in the United States, excluding intake from supplements, which favor calcium over magnesium. The prevalence and incidence of type 2 diabetes in the United States increased sharply between 1994 and 2001 as the ratio of calcium-to-magnesium intake from food rose from <3.0 to >3.0. Dietary Reference Intakes determined by balance studies may be misleading if subjects have chronic latent magnesium deficiency but are assumed to be healthy. Cellular magnesium deficit, perhaps involving TRPM6/7 channels, elicits calcium-activated inflammatory cascades independent of injury or pathogens. Refining the magnesium requirements and understanding how low magnesium status and rising calcium-to-magnesium ratios influence the incidence of type 2 diabetes, metabolic syndrome, osteoporosis, and other inflammation-related disorders are research priorities.

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Available from: Andrea Rosanoff, Jan 07, 2014
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    • "In a recent study we found that COL6A1, FN1 and CALD1 were all alternatively spliced in colorectal cancer [11]. Most of the genes with the maximum decreased expression levels have also been previously reported AQP8, GUCA2A, GUCA2B, CLCA4, CA4, ZG16 [11], CD177[26], MS4A12 [27], TRPM6 [28], ABCG2 [29] and OSTBeta [30]. Colorectal cancers arise sporadically due to multiple somatic mutations and genetic instability. "
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    Genomics 12/2013; 103(2-3). DOI:10.1016/j.ygeno.2013.11.003 · 2.28 Impact Factor
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    • "While increasing grain yields have provided a 35 % rise in per capita calories (joules) per day for the world human population (Welch 2002), increasing wheat yields of the past 40 years have come with decreasing concentrations of magnesium (Mg) (Murphy et al. 2008; Fan et al. 2008; Ficco et al. 2009). Low nutritional Mg status has been associated with the NCDs targeted by the World Health Organization (Rosanoff 2012; Seelig 1980). Magnesium is also related to the NCD risk factors so closely watched by medicine and public health organizations, e.g. "
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    Plant and Soil 07/2013; 368(1-2):139-153. DOI:10.1007/s11104-012-1471-5 · 2.95 Impact Factor
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