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    ABSTRACT: 3rd Ed Bibliogr. na konci kapitol
    Journal of Pediatric Hematology/Oncology 01/2004; 21(6). · 0.90 Impact Factor
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    ABSTRACT: To analyze the results obtained in a prospective group of patients with basal or squamous cell skin carcinomas of the face treated by high-dose-rate (HDR) brachytherapy via custom-made surface molds. A total of 136 patients with basal or squamous cell carcinomas of the face were treated between March 1992 and March 1997 by surface molds and HDR brachytherapy with iridium-192. Nineteen patients were treated with standard Brock applicators and 117 patients with custom-made polymethyl methacrylate applicators, built over a plaster mold obtained of the patient's face. Minimum dose administered to the tumor was 6000 to 6500 cGy in 33 to 36 fractions at 180 cGy/fraction in lesions of up to 4 cm. Lesions greater than 4 cm were boosted up to 7500-8000 cGy after a 3-week pause. With the custom-made surface molds, the dose distribution was uniform in the surface of the skin and at 5 mm depth in the whole area of the applicator. Differences between the areas of maximum and minimum dose at this depth never reached values higher than 5% of the prescribed dose. At the edges of the custom-made molds dose gradient was sharp, with the detected dose at 5 mm from the applicator being negligible. All the patients were complete responders. There were 3 local recurrences, 1/73 patients treated for primary tumor and 2/63 patients treated for recurrent tumor. Actuarial local control at 5 years for all patients was 98%, for those patients with primary tumors 99%, and for recurrent patients 87%. The treatment tolerance was excellent in all cases. No severe, early, or late, complications were detected. Radiotherapy is a highly effective treatment of skin carcinomas of the face. Custom-made molds, to be used in conjunction with HDR brachytherapy equipment, make possible a uniform dose distribution, with a sharp dose gradient in the limits of applicators. Custom-made surface molds are easy and safe to use, and they fit very accurately for daily treatment. Local control is excellent with minimal sequelae or complications. Probably they will become the standard way of treatment of face skin carcinomas in the near future.
    International Journal of Radiation OncologyBiologyPhysics 05/2000; 47(1):95-102. DOI:10.1016/S0360-3016(99)00547-7 · 4.26 Impact Factor
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    ABSTRACT: We are presenting a method of calculating the dose-rate distributions in partially shielded field. An attenuator was placed in central beam axis and also in an off-axis geometry. The study was made with a Co-60 radiation and with photons generated by 10 and 23 MV Linac at depths, in phantom, from 5 to 30 cm. To obtain the calculated values of dose-rates; the contributions of the three components to the total dose-rate were measured. The calculated dose-rate distributions agree well with the measured data in case of 10 MV and 23 MV radiation.
    Strahlentherapie und Onkologie 12/1990; 166(11):733-7. · 2.91 Impact Factor
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