Comparison of cardiovascular disease risk in two main forms of periodontitis.
ABSTRACT C-reactive protein (CRP) is an acute phase reactant and has been proved to be a significant predictor of future cardiovascular events. Recent studies have demonstrated a correlation between periodontitis and elevated CRP levels. However, comparison between the levels of CRP in two main forms of periodontitis is ambiguous. This study aims at determining and comparing the relative levels of serum CRP in aggressive and chronic periodontitis patients.
A total of 240 systemically healthy subjects were divided into three groups of 80 based on having generalized aggressive periodontitis, chronic generalized periodontitis and non-periodontitis (NP; controls). Venous blood samples were collected for quantitative CRP analysis using turbidimetric immunoassay.
Mean CRP levels were significantly greater in both generalized aggressive periodontitis (7.49±2.31 mg/l) and chronic generalized periodontitis (4.88±1.80 mg/l) groups as compared to NP (0.68±0.23 mg/l) controls. Moreover, CRP levels were significantly higher in aggressive periodontitis as compared to chronic periodontitis patients. Also, CRP levels positively correlated with the amount of periodontal destruction as measured by probing depth and clinical attachment loss for both chronic generalized periodontitis and generalized aggressive periodontitis.
Findings of the present study indicated that periodontitis should be of particular concern in younger individuals, where elevated levels of CRP may contribute to early or more rapid cardiovascular disease in susceptible patients. Thus, further research should be carried out at a community level to ascertain these findings.
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ABSTRACT: The success of combined periodontal and orthodontic approach in the treatment of aggressive periodontitis patients with the pathologic extruded anterior teeth is a main concern and stability of the treatment results is an important factor to evaluate the treatment. The present study investigated the periodontal parameters at the end of the orthodontic treatment in patients with the aggressive periodontitis. Eight patients with an aggressive periodontal disease, extruded maxillary incisors, infrabony defects and probing depth of ≥5 mm were enrolled in this clinical trial (before, after). After periodontal therapy, orthodontic treatment was carried out for intrusion and alignment of teeth. Plaque index (PI), probing pocket depth (PPD), distance between incisal edge and interdental papilla, root length (RL), and defect dimensions (depth and width) were examined at the end of treatment and three as well as 6 months afterward. The data were subjected to repeated measure ANOVA test. P < 0.05 was considered as significant. There was statistically significant decrease in PPD, PI, and depth of the defects during T0, T3 and T6 (P < 0.05). No significant differences were observed in the RL and distance between incisal edge and interdental papilla (P = 0.95). Furthermore, width of the defects demonstrated significant decrease up to T3 (P = 0.042) while no significant changes from 3 months to 6 months were noted (P = 0.59). The results showed that combined periodontal and orthodontic approach would be a successful treatment with acceptable stability in the case of regular follow-up visits and controlled oral hygiene habits.Dental research journal 11/2013; 10(6):744-51.
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ABSTRACT: Several studies have hypothesized that periodontal diseases may increase the risk of preeclampsia. The purpose of this study was to compare periodontal parameters in preeclamptic and normotensive pregnant women 48 hours after delivery. A case-control study was carried out on 26 pure preeclamptic women and 25 women with normal pregnancy. The participants did not have any systemic disease that may affect both preeclampsia and periodontal conditions. Clinical parameters measured in case and control groups include attachment loss, gingival bleeding index, and plaque index. These indices were measured in all teeth except the third molars. The data from each subject were reported in mean and finally the average amount of each group was compared to others and analyzed using SPSS software, t-test, and Mann-Whitney test. Mean of gestational age at delivery in preeclamptic and normotensive groups was respectively 33.2 ± 3.89 weeks and 36.5 ± 3.08 weeks. A significant difference was observed in preeclamptic women compared to controls (P = 0.01). There were no statistical differences between groups with regard to mean clinical attachment loss (P = 0.16), mean gingival bleeding (P = 0.89), and mean plaque (P = 0.95) indices. The present study showed that maternal periodontal diseases during pregnancy are not associated with preeclampsia.Dental research journal 11/2012; 9(6):770-3.