Disease Tolerance as a Defense Strategy

Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Science (Impact Factor: 33.61). 02/2012; 335(6071):936-41. DOI: 10.1126/science.1214935
Source: PubMed


The immune system protects from infections primarily by detecting and eliminating the invading pathogens; however, the host organism can also protect itself from infectious diseases by reducing the negative impact of infections on host fitness. This ability to tolerate a pathogen's presence is a distinct host defense strategy, which has been largely overlooked in animal and human studies. Introduction of the notion of "disease tolerance" into the conceptual tool kit of immunology will expand our understanding of infectious diseases and host pathogen interactions. Analysis of disease tolerance mechanisms should provide new approaches for the treatment of infections and other diseases.

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Available from: David Schneider, Jun 28, 2015
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    • "It remains to be determined whether there is a benefit to the host or whether, alternatively, the pathogen-induced oxidative stress represents simply a metabolic by-product of the IFN-I driven response. We speculate that this process might bear relevance for the metabolic rewiring of the cell, whereby the IFN-I driven transient changes in the redox status contribute to the rapidly changing bioenergetic and signaling demands as part of the antiviral state and/or of mechanisms of disease tolerance (Everts et al., 2014; Medzhitov et al., 2012; Pantel et al., 2014; Schieber and Chandel, 2014; Weinberg et al., 2015). The molecular understanding of such crosstalk between metabolic and inflammatory processes might also contribute to a better understanding of the mechanism(s) of action and side effects of IFN-I therapies in non-infectious diseases like multiple sclerosis and cancer (Reder and Feng, 2014; Sistigu et al., 2014). "
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    Immunity 11/2015; 43(5):974-986. DOI:10.1016/j.immuni.2015.10.013 · 21.56 Impact Factor
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    • "Distinguishing between resistance and disease tolerance is useful because they are fundamentally different strategies for surviving challenges. Applying the concepts of resistance and disease tolerance has improved our understanding of pathogenic infections (Iwasaki and Pillai, 2014; Medzhitov et al., 2012; Rå berg, 2014; Vale et al., 2014) and should be applicable to any insult to host health, like cancer, not just infectious disease. We established a model to separate resistance and tolerance to cancer to understand the role of these immunological processes in cancer infections. "
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