Article

Mitosis: Short-Circuiting Spindle Checkpoint Signaling

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Current biology: CB (Impact Factor: 9.92). 02/2012; 22(4):R128-30. DOI: 10.1016/j.cub.2012.01.018
Source: PubMed

ABSTRACT The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

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