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A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals.

Scientific Reports (Impact Factor: 5.08). 01/2012; 2:280. DOI: 10.1038/srep00280
Source: PubMed

ABSTRACT Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may be applicable to various human solid tumor cells that express aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors (RXRs).

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