Article

Chemoprevention of pancreatic cancer-one step closer.

Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Langenbeck s Archives of Surgery (impact factor: 1.81). 02/2012; 397(4):495-505. DOI:10.1007/s00423-012-0916-x pp.495-505
Source: PubMed

ABSTRACT BACKGROUND: Since for pancreatic cancer the mortality rate approaches the incidence rate with only 1-4% of all patients surviving 5 years, it would be would be of great value to provide chemopreventive treatment for high-risk individuals. DISCUSSION: The preclinical study of pancreatic intraepithelial neoplasia (PanINs) has recently been made possible by the generation of genetically modified animal models, which recapitulate human PanINs and invasive pancreatic cancer on a genetic and histomorphologic level. Very recently, several groups have reported first evidence of chemoprevention of pancreatic cancer.

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Keywords

animal models
 
chemoprevention
 
great value
 
histomorphologic level
 
incidence rate
 
invasive pancreatic cancer
 
pancreatic cancer
 
pancreatic intraepithelial neoplasia
 
PanINs
 
possible
 
preclinical study
 
recapitulate human PanINs
 

Volker Fendrich