Chemoprevention of pancreatic cancer-one step closer.

Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Langenbeck s Archives of Surgery (Impact Factor: 1.89). 02/2012; 397(4):495-505. DOI: 10.1007/s00423-012-0916-x
Source: PubMed

ABSTRACT BACKGROUND: Since for pancreatic cancer the mortality rate approaches the incidence rate with only 1-4% of all patients surviving 5 years, it would be would be of great value to provide chemopreventive treatment for high-risk individuals. DISCUSSION: The preclinical study of pancreatic intraepithelial neoplasia (PanINs) has recently been made possible by the generation of genetically modified animal models, which recapitulate human PanINs and invasive pancreatic cancer on a genetic and histomorphologic level. Very recently, several groups have reported first evidence of chemoprevention of pancreatic cancer.

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