Article

Reduced Expression of PER3 Is Associated with Incidence and Development of Colon Cancer.

Department of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Annals of Surgical Oncology (impact factor: 4.17). 02/2012; 19(9):3081-8. DOI:10.1245/s10434-012-2279-5
Source: PubMed

ABSTRACT Period 3 (PER3), a circadian regulation protein, influences cell cycle, growth, and differentiation. The aim of the present study was to determine whether PER3 expression is associated with colon cancer incidence and progression.
PER3 expression was analyzed in the normal and cancerous tissues from patients with colon cancer by establishing a long serial analysis of gene expression (SAGE) database as well as by real-time PCR and immunohistochemistry.
As compared with normal tissue, a 2.8-fold decrease in PER3 mRNA levels in colon cancerous tissue was observed. Real-time PCR analysis revealed that PER3 mRNA levels in tumor tissues were lower than in normal tissues (P < 0.001) in both patients with colon tumor and those with rectal tumor. In addition, PER3 expression was related to multiple clinicopathologic factors, including tumor location, differentiation, and stage. Furthermore, the incidence of death was higher in subjects with PER3-negative tumors (P = 0.025); the estimated overall survival time was 71.5 ± 2.2 months and 58.6 ± 5.0 months in subjects with PER3-positive and PER3-negative tumors, respectively (P = 0.020).
PER3 may play a role in colon cancer progression.

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Keywords

cancerous tissues
 
circadian regulation protein
 
colon cancer
 
colon cancer incidence
 
colon cancer progression
 
colon cancerous tissue
 
influences cell cycle
 
multiple clinicopathologic factors
 
normal tissue
 
normal tissues
 
PER3 expression
 
PER3 mRNA levels
 
PER3-negative tumors
 
Period 3
 
real-time PCR
 
Real-time PCR analysis
 
rectal tumor
 
serial analysis
 
survival time
 
tumor tissues
 

Xiaoliang Wang