Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis

Centre de Génétique Moléculaire du CNRS, UPR 3404, FRC3115, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Mitochondrion (Impact Factor: 3.25). 02/2012; 12(3):381-90. DOI: 10.1016/j.mito.2012.02.002
Source: PubMed


Complexes III and IV of the mitochondrial respiratory chain contain a few key subunits encoded by the mitochondrial genome. In Saccharomyces cerevisiae, fifteen mRNA-specific translational activators control mitochondrial translation, of which five are conserved in Schizosaccharomyces pombe. These include homologs of Cbp3, Cbp6 and Mss51 that participate in translation and the post-translational steps leading to the assembly of respiratory complexes III and IV. In this study we show that in contrast to budding yeast, Cbp3, Cbp6 and Mss51 from S. pombe are not required for the translation of mitochondrial mRNAs, but fulfill post-translational functions, thus probably accounting for their conservation.

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Available from: Inge Kühl, Oct 06, 2015
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    • "The sequences retrieved in Y. lipolytica, N. crassa and S. pombe are significantly closer to Pan5 than to Cbs2 by reciprocal Blast searches, suggesting that the actual Cbs2 protein is probably not conserved in these three organisms. b According to Kühl et al. [133] [134]. c According to Perez-Martinez et al. [120]. "
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